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Synthesis of 3,4,5‐Trisubstituted Isoxazoles via the ANRORC Rearrangement
Author(s) -
Kandula Venu,
Bandaru Sravan K.,
Balakrishna C.,
Chatterjee Anindita,
Yennam Satyanarayana,
Saunders Graham C.,
Behera Manoranjan
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001103
Subject(s) - chemistry , isoxazole , oxime , combinatorial chemistry , organic chemistry
A facile and versatile procedure for the synthesis of new functionalized derivatives of 3‐benzyl‐5‐(2‐hydroxyphenyl) isoxazole‐4‐carbaldehyde oxime has been described. The key step in the synthesis involves the ANRORC reaction of in‐situ generated 3‐(phenylethynyl)‐4H‐chromen‐4‐one with NH 2 OH · HCl.

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