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Complexes Formed between Artificial Receptors and β‐Glucopyranoside in the Crystalline State
Author(s) -
Köhler Linda,
Seichter Wilhelm,
Mazik Monika
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001101
Subject(s) - chemistry , molecular recognition , carbohydrate , context (archaeology) , receptor , crystal structure , computational biology , biochemistry , molecule , stereochemistry , crystallography , organic chemistry , biology , paleontology
In contrast to numerous known crystal structures of protein‐carbohydrate complexes, which act as a source of structural information about carbohydrate‐mediated recognition processes, there are only individual literature reports on crystal structures of complexes formed between artificial receptors and sugars. In this context, the new crystalline complexes of acyclic receptors and β‐ d ‐glucopyranoside described in this article provide particularly valuable model systems to study the basic molecular features of carbohydrate recognition. The detailed analyses of the binding modes observed in these complexes have shown their remarkable similarity to those used by carbohydrate‐binding proteins. It is noteworthy that many of the basic molecular features of protein‐carbohydrate interactions, that have been summarized years ago in some literature reports, apply to interactions observed in complexes formed by the artificial receptors.