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Metal‐Free Electrochemical Oxidative Dihalogenation of Quinolines on the C5 and C7 Positions Using N ‐Halosuccinimides
Author(s) -
Hou Jiahao,
Wang Kai,
Zhang Changjun,
Wei Tingting,
Bai Renren,
Xie Yuanyuan
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001066
Subject(s) - chemistry , halogen , electrochemistry , transition metal , oxidative phosphorylation , combinatorial chemistry , metal , organic chemistry , electrode , catalysis , biochemistry , alkyl
An efficient and convenient method for electrochemically oxidative dichlorination or dibromination of 8‐aminoquinolines on C5 and C7 positions using N ‐halosuccinimides (NCS and NBS) as the halogen source was described. Substrates with various functional groups were transformed smoothly and the halogenated products were obtained in good to excellent yields. These transformations feature transition‐metal‐free, oxidant‐free, and short reaction time.