Premium
Cover Feature: One‐Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α‐Aryl‐α‐Trifluoromethyl Alcohols (Eur. J. Org. Chem. 29/2020)
Author(s) -
Kani Ryunosuke,
Inuzuka Toshiyasu,
Kubota Yasuhiro,
Funabiki Kazumasa
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202001036
Subject(s) - trifluoromethyl , chemistry , aryl , functional group , reagent , combinatorial chemistry , organic chemistry , polymer , alkyl
The Cover Feature shows a novel straightforward one‐pot synthetic methodology involving two successive reactions of the turbo Grignard reagent for the synthesis of α‐aryl or α‐heteroaryl‐α‐trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional group tolerance, including reducible groups. The arrow highlights the rapid synthesis of the desired trifluoromethyl alcohols from commercial available chemicals. More information can be found in the Communication by K. Funabiki et al.