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Consecutive Oxidation/Condensation/Cyclization/Aromatization Sequences Catalyzed by Nanostructured Iron(III)‐Porphyrin Complex towards Benzoxazole Derivatives
Author(s) -
Aboonajmi Jasem,
Sharghi Hashem,
Aberi Mahdi,
Shiri Pezhman
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000999
Subject(s) - benzoxazole , chemistry , porphyrin , aromatization , oxidizing agent , catalysis , combinatorial chemistry , condensation , catalytic oxidation , oxidation process , photochemistry , organic chemistry , chemical engineering , physics , thermodynamics , engineering
A facile, efficient, and eco‐friendly strategy to access benzoxazole heterocyclic products has been accomplished through oxidation of catechols followed by condensation/cyclization/aromatization sequences. This process is catalyzed by nanostructured iron(III)‐porphyrin complex to form desired benzoxazole derivatives at room temperature under air condition. The procedure is widely applicable to diverse amines, and can provide the heterocyclic products in a scalable fashion, as well. One of the most significant types of oxidizing agents in nature is the iron‐porphyrin complexes (0.1 mol‐%), existing in the structure of hemoglobin. They have benefits such as low toxicity and high oxidation potential for many substrates.