A Facile Synthesis of 3‐(Arylthio)imidazo[1,2‐ a ]pyridin‐2(3H)‐ones from 2‐Aminopyridinium Bromides and Sodium Arenesulfinates | Zendy

Rangan Krishnan | Zendy; Kumar Anil | Zendy

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A Facile Synthesis of 3‐(Arylthio)imidazo[1,2‐ a ]pyridin‐2(3H)‐ones from 2‐Aminopyridinium Bromides and Sodium Arenesulfinates

Author(s) -

Rangan Krishnan,

Kumar Anil

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202000996

Subject(s) - chemistry , substrate (aquarium) , catalysis , combinatorial chemistry , sodium , medicinal chemistry , functional group , one step , scope (computer science) , stereochemistry , organic chemistry , art , oceanography , computer science , visual arts , programming language , geology , polymer

A simple and convenient method has been developed for the synthesis of 3‐(arylthio)imidazo[1,2‐ a ]pyridin‐2(3H)‐ones through a catalyst‐free reaction of 2‐aminopyridinium bromides with sodium arenesulfinates. A variety of 3‐(arylthio)imidazo[1,2‐ a ]pyridin‐2(3H)‐ones were obtained in moderate to excellent (33–85 %) yields. The developed protocol is operationally simple, exhibits a broad substrate scope with a wide range of functional groups, and is amenable for gram‐scale synthesis.

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