Premium
Transition‐Metal‐Free Annulation of Enamines and Tosyl Azide toward N‐Heterocycle Fused and 5‐Amino‐1,2,3‐Triazoles
Author(s) -
Deng Leiling,
Liu Yunyun,
Zhu Yanping,
Wan JiePing
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000938
Subject(s) - annulation , chemistry , tosyl , azide , transition metal , ketene , combinatorial chemistry , side chain , stereochemistry , organic chemistry , catalysis , polymer
The annulation reactions between gem ‐diamino enaminones (ketene aminals) and tosyl azide providing N‐heterocycle fused and 5‐amino side chain functionalized 1,2,3‐triazoles have been developed. The synthesis of these N‐side chain functionalized 1,2,3‐triazoles has been executed with high efficiency and broad synthetic scope under transition metal‐free conditions with the assistance of NaHCO 3 only.