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One‐Pot Synthesis of Highly Substituted Quinolines in Aqueous Medium and Its Application for the Synthesis of Azalignans
Author(s) -
Kumar Amrendra,
Prajapati Ramanand,
Kant Ruchir,
Narender Tadigoppula
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000906
Subject(s) - chemistry , ammonium bromide , amide , aqueous solution , glycine , organic chemistry , sodium dodecyl sulfate , ketone , ammonium acetate , bromide , pulmonary surfactant , one pot synthesis , quinoline , combinatorial chemistry , amino acid , catalysis , biochemistry , high performance liquid chromatography
A new one‐pot method has been developed for the synthesis of highly substituted quinoline derivatives from α‐amino ketone derivatives/glycine esters/glycine amide and aromatic/aliphatic alkynes/alkenyl esters using molecular I 2 , K 2 CO 3 , and tetra butyl ammonium bromide (TBAB) and sodium dodecyl sulfate (SDS) surfactant combination in water at room temperature within 30–50 min. in moderate to good yields. This protocol has advantages like oxidant free, aqueous medium, simple operation, tolerance of various substrates, and useful for the synthesis of bioactive aza‐lignans.