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A Review on Oxidative Gold‐Catalyzed C‐H Arylation of Arenes – Challenges and Opportunities
Author(s) -
Fricke Christoph,
Reid William B.,
Schoenebeck Franziska
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000856
Subject(s) - chemistry , catalysis , scope (computer science) , lewis acids and bases , combinatorial chemistry , palladium , nanotechnology , oxidative addition , organic chemistry , materials science , computer science , programming language
Cross‐coupling strategies have become essential in modern organic synthesis. While palladium has historically dominated this field, other transition metals have arisen as potent and orthogonal alternatives. Gold, typically thought of as just a Lewis acid, has recently demonstrated redox chemistry in several cross‐coupling reactions using an external oxidant. One of these branches, oxidative C–H functionalizations, has made significant advances in recent years. Herein, we discuss the discovery and development of gold catalysis in this realm with particular focus on improvements in scope and mechanistic understandings in relation to biaryl couplings.