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A Novel Bisoxazoline‐Imidazolium Salt in Ytterbium‐Catalyzed Asymmetric Reduction of Ketone
Author(s) -
Zhai Yujie,
Xu Wenhao,
Wang Dong,
Zheng Purui,
Zhao Xiaoming,
XU Tao
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000816
Subject(s) - chemistry , carbene , denticity , ketone , salt (chemistry) , chelation , catalysis , ligand (biochemistry) , ytterbium , combinatorial chemistry , asymmetric hydrogenation , organometallic chemistry , enantioselective synthesis , medicinal chemistry , organic chemistry , crystal structure , doping , biochemistry , physics , receptor , optoelectronics
Chiral N‐heterocyclic carbene (NHC), a privileged ligand for transition metals, has had a profound impact on organometallic chemistry. The monodentate and bidentate chiral carbenes have been developed significantly, while the tridentate ones have been less exploited. Herein, we designed and synthesized a new bisoxazoline‐imidazolium salt as a carbene precursor, which owns three chelating sites and two kinds of chiral information centers. A preliminary investigation on the asymmetric ketone reduction was also studied.