Premium
An Overview on the Chemical N ‐Functionalization of Sugars and Formation of N ‐Glycosides
Author(s) -
Sangwan Rekha,
Khanam Ariza,
Mandal Pintu Kumar
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000813
Subject(s) - chemistry , surface modification , glycosyl , glycoside , carbohydrate chemistry , organic chemistry , chemical modification , amide , combinatorial chemistry , biochemistry
Its even more than a centennial that the systematic researches of chemical alteration of sugars have been advancing. Out of all the interest in the field of N ‐glycoside has assembled pace over the past few years. Therefore, N ‐functionalization of sugar is one of the most fundamental modifications along with other group like azide, amide etc also play a remarkable role in the field of glycoscience. Different approaches to access structurally modified N ‐glycosides in carbohydrate derivatives are reviewed. The goal of this review is to provide an overview of different way of N ‐functionalization of amino sugar and induction of nitrogen scaffolds for the synthesis of various orthogonal protective groups of the N ‐glycoside. The N ‐functionalization of sugars designate as follows: (a) glycosylamine, (b) glycosyl azide, and (c) introduction of N ‐functionality to the sugar for formation of N ‐glycosides. This is the first review focus on N ‐functionalization of sugars which will be a future scope that influence the readers to work in this area further.