Premium
Low Molecular Weight Di‐ to Tetrapeptide Transmembrane Cation Transporters
Author(s) -
Benke Bahiru P.,
Behera Harekrushna,
Madhavan Nandita
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000686
Subject(s) - tetrapeptide , chemistry , transmembrane protein , transporter , bilayer , transmembrane domain , halide , alkali metal , lipid bilayer , amino acid , combinatorial chemistry , stereochemistry , peptide , biochemistry , organic chemistry , membrane , receptor , gene
Low molecular weight di‐, tri‐ and tetrapeptide transmembrane ion transporters containing aminobenzoic acid and l / d alanine are reported. These short peptides transport alkali metal cations in preference to halides across the lipid bilayer most likely through a carrier mechanism. Easy access to these peptides and the ability to install diverse functional groups into the peptidic scaffold make them attractive scaffolds for therapeutic use.