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A Decade of Muricatacin Synthesis and Beyond
Author(s) -
Fernandes Rodney A.,
Gangani Ashvin J.,
Kumari Anupama,
Kumar Praveen
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000665
Subject(s) - acetogenin , chemistry , enantioselective synthesis , enantiomer , stereochemistry , epimer , combinatorial chemistry , catalysis , organic chemistry , medicine , annonaceae , traditional medicine
In this review, we have abstracted the various syntheses of both enantiomers of muricatacin (a member of a bigger class of acetogenins, ACGs), over the last decade (2010–2020). Developments in the synthesis of various epimers, homologues, oxa‐analogues, δ‐lactones, and the furofuranone analogues are also enfolded in this review. Most of the synthesis involve chiral pool and catalytic enantioselective approaches, while a few are hinged on the use of chiral auxiliary and resolution methods. Muricatacin with orthogonally differentiated two oxy‐functions also serve as a start point in the synthesis of higher molecules of the acetogenin family, for example, cis ‐solamins, and these have also been covered herein.