Premium
Cover Feature: tert ‐Butyl 3‐Diazo‐2‐oxopyrrolidine‐1‐carboxylate – A New Reagent for Introduction of the 2‐Oxopyrrolidin‐3‐yl Motif via Rh II ‐Catalyzed X–H Insertion Reactions (Eur. J. Org. Chem. 20/2020)
Author(s) -
Zhukovsky Daniil,
Dar'in Dmitry,
Krasavin Mikhail
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000639
Subject(s) - chemistry , moiety , reagent , diazo , catalysis , carboxylate , nitrogen atom , molecule , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , group (periodic table)
The Cover Feature shows “King Boc and His flock”. N‐Boc‐protected 3‐diazo2‐pyrrolidone is a new versatile reagent for introducing the privileged 2‐pyrrolidone motif to various molecules via a Rh(II)‐catalyzed X‐H insertion into thiols, alcohols, and amines. Removal of the Boc group liberates the NH‐2‐pyrrolidone moiety which can, in turn be used for further modifications at the nitrogen atom or reduced to give 3‐substituted pyrrolidines, privileged building blocks on their own. More information can be found in the Full Paper by M. Krasavin et al.