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Polyenals and Polyenones in Aminocatalysis: A Decade Building Complex Frameworks from Simple Blocks
Author(s) -
Pawar Tushar Janardan,
Mitkari Suhas Balasaheb,
PeñaCabrera Eduardo,
Villegas Gómez Clarisa,
Cruz Cruz David
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000570
Subject(s) - iminium , chemistry , simple (philosophy) , organocatalysis , reactive intermediate , cascade , nanotechnology , combinatorial chemistry , ion , organic chemistry , enantioselective synthesis , catalysis , epistemology , philosophy , materials science , chromatography
Polyenals and polyenones are simple chemical compounds which can be constructed into large and complex structures by virtue of aminocatalysis. In the past eight years, new aminocatalytic activation modes based on trienamine, cross‐trienamine, tetraenamine, iminium ion, and vinylogous iminium ion intermediates have attracted great attention in the field of asymmetric synthesis. Key to the increasing focus is their inherent ability to allow functionalization of remote sites with excellent stereoselectivities. Moreover, methodologies involving one‐pot, cascade or multicomponent strategies have been developed through the combination of these new activation modes with classical activation modes. In the course of expanding the applicability of organocatalysis, polyenals and polyenones have been introduced as simple and novel substrates, which have enabled the discovery of new concepts for the synthesis of many diverse and complex privileged structures.