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Front Cover: The Binomial Copper‐Catalysis and Asymmetric Ring Opening of Strained Heterocycles: Past and Future Challenges (Eur. J. Org. Chem. 18/2020)
Author(s) -
Pineschi Mauro
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000560
Subject(s) - chemistry , ring (chemistry) , copper , front cover , nucleophile , catalysis , degree of unsaturation , heteroatom , cover (algebra) , combinatorial chemistry , metal , organic chemistry , mechanical engineering , engineering
The Front Cover shows how chiral copper catalysts promote in a unique way the asymmetric ring‐opening reactions of strained heterocycles. The coordination of the copper catalyst with the unsaturation adjacent to the heteroatom serving as leaving group triggers a variety of ring openings by changing the nucleophile bound to copper. A variety of chiral non‐racemic building blocks can be efficiently obtained with regio‐ and stereoselectivities that are complimentary to the selectivities attainable by other metal catalysts. More information can be found in the Minireview by M. Pineschi.