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Synthetic Studies towards CH‐Diazomethane Sulfonamides: a Novel Type of Diazo Reagents
Author(s) -
Bubyrev Andrey,
Dar'in Dmitry,
Kantin Grigory,
Krasavin Mikhail
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000446
Subject(s) - diazomethane , diazo , chemistry , reagent , cycloaddition , pyrazole , combinatorial chemistry , nitro , organic chemistry , catalysis , alkyl
Preparation of CH‐diazomethane sulfonamides has been developed for the first time. Their utility as a new type of diazo reagents was showcased in cycloaddition reactions with electron‐deficient alkynes and β‐nitro styrenes which delivered medicinally important pyrazole‐3‐sulfonamides in good to excellent yields.