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Rhodium‐Catalyzed Reductive Esterification Using Carbon Monoxide as a Reducing Agent
Author(s) -
Ostrovskii Vladimir S.,
Runikhina Sofiya A.,
Afanasyev Oleg I.,
Chusov Denis
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000438
Subject(s) - rhodium , chemistry , ruthenium , nucleophile , carbon monoxide , catalysis , reducing agent , reductive elimination , heteroatom , organic chemistry , combinatorial chemistry , photochemistry , ring (chemistry)
Carbon monoxide used to have a limited number of applications in organic chemistry, but it gradually increases its role as a mild and selective reducing agent. It can be applied for the carbon–heteroatom single bond formation via the reductive addition of hydrogen‐containing nucleophiles to carbonyl compounds. In this paper, rhodium‐catalyzed reductive esterification is described, and a comparative study of the rhodium and ruthenium catalysis in the reductive addition reactions is provided. Rhodium performs better on highly nucleophilic substrates and ruthenium is better for compounds with less nucleophilicity.