Cooperative Silver‐ and Base‐Catalyzed Diastereoselective Cycloaddition of Nitrones with Methylene Isocyanides: Access to 2‐Imidazolinones | Zendy

Chen Yan | Zendy; Wu Yijing | Zendy; Shatskiy Andrey | Zendy; Kan Yuhe | Zendy; Kärkäs Markus D. | Zendy; Liu JianQuan | Zendy; Wang XiangShan | Zendy

Premium

Cooperative Silver‐ and Base‐Catalyzed Diastereoselective Cycloaddition of Nitrones with Methylene Isocyanides: Access to 2‐Imidazolinones

Author(s) -

Chen Yan,

Wu Yijing,

Shatskiy Andrey,

Kan Yuhe,

Kärkäs Markus D.,

Liu JianQuan,

Wang XiangShan

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202000437

Subject(s) - chemistry , cycloaddition , diastereomer , base (topology) , catalysis , methylene , combinatorial chemistry , reaction mechanism , medicinal chemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics

A protocol involving cooperative silver‐ and base‐catalyzed diastereoselective cycloaddition of nitrones with isocyanides is described, providing access to a wide range of 2‐imidazolinone derivatives with various functional groups as single diastereomers. Varying the base and temperature of the reaction allowed selective access to both diastereomers of the product. A plausible reaction mechanism is proposed and supported by DFT calculations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research