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A Naphthalimide‐Based ND‐O‐EAc Photocatalyst for Sulfonation of Alkenes to Access β‐Ketosulfones Under Visible Light
Author(s) -
Yang Xiaoting,
Yang Jianjing,
Yan Kelu,
Qin Hongyun,
Dong Wenjie,
Wen Jiangwei,
Wang Hua
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000423
Subject(s) - photocatalysis , chemistry , visible spectrum , catalysis , substrate (aquarium) , yield (engineering) , combinatorial chemistry , photochemistry , nanotechnology , organic chemistry , materials science , oceanography , optoelectronics , metallurgy , geology
The development of facile, efficient, cost‐effective, and visible light‐driven photocatalysts for organic synthetic chemistry has received increasing attention. This protocol has initially synthesized a naphthalimide‐based ND‐O‐EAc visible light photocatalyst for the sulfonation of alkenes to produce β‐ketosulfones. Compared with the current photosynthetic strategies, the newly developed catalytic system has some merits, namely high efficiency, gram‐scale preparation of low‐cost photocatalyst, no metal contamination, wide substrate scope, and green terminal oxidant of air. Moreover, the prepared photocatalyst of ND‐O‐EAc is feasible for the sulfonation reactions of androstenones. Importantly, such a photocatalysis strategy can easily realize the scale‐up synthesis for β‐ketosulfone drugs under the mild conditions up to 90 % yield.