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Rational Optimization of Lewis‐Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst
Author(s) -
Payard PierreAdrien,
Finidori Céline,
Guichard Laurélia,
Cartigny Damien,
Corbet Matthieu,
Khrouz Lhoussain,
Bonneviot Laurent,
Wischert Raphael,
Grimaud Laurence,
PeraTitus Marc
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000413
Subject(s) - lewis acids and bases , catalysis , chemistry , amination , reactivity (psychology) , titanium , pyridine , alcohol , organic chemistry , salt (chemistry) , combinatorial chemistry , medicine , alternative medicine , pathology
The reactivity of a new titanium triflimide salt (see Part 1) was investigated for the direct amination of alcohols. The combination of this new Lewis acid with pyridine‐based ligands allowed a significant increase of activity. The scope of the reaction was increased compared to other Lewis‐acid‐based protocols. Finally, mechanistic insights based on EPR spectroscopy and DFT calculations are provided.