Highly Efficient and Convenient Access to Phosphinates via CHCl 3 ‐Assisted Direct Phosphorylation between R 2 P(O)H and ROH by Phosphonium Salt Catalysis | Zendy

Yu Xiaojun | Zendy; Zhang Song | Zendy; Jiang Zhiyu | Zendy; Zhang HongSu | Zendy; Wang Tianli | Zendy

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Highly Efficient and Convenient Access to Phosphinates via CHCl 3 ‐Assisted Direct Phosphorylation between R 2 P(O)H and ROH by Phosphonium Salt Catalysis

Author(s) -

Yu Xiaojun,

Zhang Song,

Jiang Zhiyu,

Zhang HongSu,

Wang Tianli

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202000385

Subject(s) - chemistry , phosphonium , carbene , phosphorylation , catalysis , phosphonium salt , salt (chemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry

A mild, efficient, convenient and scalable method to synthesize phosphinates via direct phosphorylation between R 2 P(O)H and ROH was developed. All aromatic substrates completed this transformation with excellent yields (up to 98 %), and preliminary mechanistic studies suggest that a carbene‐involving process from CHCl 3 to CH 2 Cl 2 facilitates the phosphorylation.

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