Premium
Highly Efficient and Convenient Access to Phosphinates via CHCl 3 ‐Assisted Direct Phosphorylation between R 2 P(O)H and ROH by Phosphonium Salt Catalysis
Author(s) -
Yu Xiaojun,
Zhang Song,
Jiang Zhiyu,
Zhang HongSu,
Wang Tianli
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000385
Subject(s) - chemistry , phosphonium , carbene , phosphorylation , catalysis , phosphonium salt , salt (chemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry
A mild, efficient, convenient and scalable method to synthesize phosphinates via direct phosphorylation between R 2 P(O)H and ROH was developed. All aromatic substrates completed this transformation with excellent yields (up to 98 %), and preliminary mechanistic studies suggest that a carbene‐involving process from CHCl 3 to CH 2 Cl 2 facilitates the phosphorylation.