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gem ‐Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF 3 SiMe 3 –NaI System
Author(s) -
Hryshchuk Oleksandr V.,
Varenyk Anatolii O.,
Yurov Yevhen,
Kuchkovska Yuliya O.,
Tymtsunik Andriy V.,
Grygorenko Oleksandr O.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000346
Subject(s) - chemistry , bicyclic molecule , yield (engineering) , potassium , medicinal chemistry , radiochemistry , organic chemistry , stereochemistry , materials science , metallurgy
Difluorocyclopropanation of alkenyl trifluoroborates using TMSCF 3 –NaI system was reported for the first time. The developed method allowed preparation of monocyclic, spiro‐ and fused‐bicyclic gem ‐difluorocyclopropanes bearing additional functional groups. The preparation of potassium (2,2‐difluorocyclopropyl)trifluoroborates was achieved in up to 90 % yield on a multigram scale.