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Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom
Author(s) -
Blahun Oleksandr P.,
Melnychenko Heorhii,
Kuchkovska Yuliya O.,
Zhersh Serhii,
Tolmachev Andrey A.,
Grygorenko Oleksandr O.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000314
Subject(s) - bicyclic molecule , chemistry , nitrogen atom , carboxylation , stereochemistry , combinatorial chemistry , organic chemistry , ring (chemistry) , catalysis
Two approaches to the synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead nitrogen atom were developed. The target compounds were obtained either by introduction of a CH 2 SO 2 bridge into functionalized monocyclic substrates or by final‐step carboxylation of parent bicyclic cores. The described methods allowed preparation of the final products on a multigram scale.