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Multivalent and Multifunctional Calixarenes in Bionanotechnology
Author(s) -
Baldini Laura,
Casnati Alessandro,
Sansone Francesco
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000255
Subject(s) - chemistry , calixarene , combinatorial chemistry , nanomedicine , amphiphile , nanobiotechnology , nanotechnology , nanoparticle , organic chemistry , polymer , molecule , copolymer , materials science
The key features of calixarene derivatives as multivalent ligands for biomacromolecules and as multifunctional catalysts are reviewed herein. The ease of functionalization and the possibility to control the regio‐ and stereochemical disposition of multiple ligating units around a central core allow to obtain ligands with high affinity and selectivity especially for proteins and nucleic acids. The hydrophilic/lipophilic character can also be finely tuned, allowing to obtain monomeric hybrid derivatives or amphiphiles able to self‐assemble alone or in co‐formulation with lipids to give nanoparticles and liposomes that incorporate calixarenes. The knowledge acquired up to now sheds light on the future applications of calixarenes in bionanotechnology and nanomedicine.