Synthesis of Chiral 3,4‐Disubstituted Pyrrolidines with Antibacterial Properties | Zendy

Rodriguez Lenka | Zendy; Fišera Roman | Zendy; Gaálová Barbora | Zendy; Koči Kamila | Zendy; Bujdáková Helena | Zendy; Mečiarová Mária | Zendy; Górová Renáta | Zendy; Jurdáková Helena | Zendy; Šebesta Radovan | Zendy

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Synthesis of Chiral 3,4‐Disubstituted Pyrrolidines with Antibacterial Properties

Author(s) -

Rodriguez Lenka,

Fišera Roman,

Gaálová Barbora,

Koči Kamila,

Bujdáková Helena,

Mečiarová Mária,

Górová Renáta,

Jurdáková Helena,

Šebesta Radovan

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202000235

Subject(s) - chemistry , pyrrolidine , combinatorial chemistry , escherichia coli , staphylococcus aureus , antibacterial activity , organocatalysis , antibiotics , enantioselective synthesis , organic chemistry , stereochemistry , bacteria , catalysis , biochemistry , genetics , biology , gene

Chiral aliphatic heterocycles are important structural feature of many pharmaceutical agents. Antibiotic resistance is a serious medical problem, therefore new antibacterial compounds are urgently needed. Herein, we describe synthesis of a series of 3,4‐disubstituted pyrrolidine derivatives via organocatalytic Michael addition followed by reductive cyclization. These compounds inhibited growth of standard as well as methicillin‐resistant strains of Escherichia coli and Staphylococcus aureus .

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