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Front Cover: Efficient Synthesis of Antigenic Trisaccharides Containing N ‐Acetylglucosamine: Protection of NHAc as NAc 2 (Eur. J. Org. Chem. 12/2020)
Author(s) -
Tsutsui Masato,
Sianturi Julinton,
Masui Seiji,
Tokunaga Kento,
Manabe Yoshiyuki,
Fukase Koichi
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000225
Subject(s) - chemistry , n acetylglucosamine , front cover , glycosylation , glycan , combinatorial chemistry , acetamide , stereochemistry , hydrogen bond , intermolecular force , cover (algebra) , organic chemistry , molecule , biochemistry , glycoprotein , enzyme , mechanical engineering , engineering
The Front Cover shows diacetyl strategy. This new synthetic strategy can contribute to efficient synthesis of glycans containing amino sugars. Acetamide (NHAc) is tentatively converted to diacetylimide (NAc 2 ) during oligosaccharide construction. Because NAc 2 protected fragments cannot form intermolecular hydrogen bonding, this strategy can improve the reactivity in glycosylation to realize the efficient construction of glycans. More information can be found in the Full Paper by Y. Manabe, K. Fukaseet al.