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Continuous‐Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase–Oxovanadium Cocatalysis
Author(s) -
Higashio Koichi,
Katsuragi Satoko,
Kundu Dhiman,
Adebar Niklas,
Plass Carmen,
Kühn Franziska,
Gröger Harald,
Akai Shuji
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000186
Subject(s) - kinetic resolution , chemistry , catalysis , lipase , flow chemistry , turnover number , mixing (physics) , batch reactor , continuous reactor , organic chemistry , microreactor , alcohol , continuous flow , packed bed , chromatography , enantioselective synthesis , enzyme , physics , quantum mechanics , mechanics
A continuous‐flow dynamic kinetic resolution of racemic secondary alcohols was carried out using a single column reactor packed with a mixture of immobilized lipase and an immobilized oxovanadium species, VMPS4. As a result, optically pure esters were produced in 88–92 % yields. Problems encountered in this study were overcome by using fillers that efficiently maintained the initial distribution of the catalysts in the reactor and by using a packing method in which the mixing ratio of the two catalysts was varied in a stepwise fashion. The flow process led to an increased turnover number of each catalyst compared to those of batch reactions.