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Iodine‐Mediated Condensation–Cyclization of α‐Azido Ketones with p ‐Toluenesulfonyl Hydrazide for Synthesis of 4‐Aryl‐ NH ‐1,2,3‐Triazoles
Author(s) -
Ren MingTian,
Li Min,
Wang AnJing,
Gao Jie,
Zhang XiangXiang,
Shu WenMing
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000146
Subject(s) - chemistry , hydrazide , iodine , aryl , condensation , condensation reaction , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics , alkyl
A molecular iodine mediated condensation–cyclization reaction for the synthesis of 4‐aryl‐ NH ‐1,2,3‐triazoles has been developed from readily available α‐azido acetophenones and p ‐toluenesulfonyl hydrazide. This reaction provides a metal‐free strategy for the sequential formation of C–N and N–N bonds in mild condition.