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Palladium‐Catalyzed Cyanation of Aryl Halides Using Formamide and Cyanuric Chloride as a New “CN” Source
Author(s) -
Niknam Esmaeil,
Panahi Farhad,
KhalafiNezhad Ali
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000117
Subject(s) - cyanation , cyanuric chloride , chemistry , formamide , aryl , palladium , reagent , catalysis , halide , cyanuric acid , chloride , organic chemistry , combinatorial chemistry , aryl halide , melamine , polymer chemistry , alkyl
A new source of “CN” employing formamide and cyanuric chloride is introduced for the cyanation reactions. The treatment of formamide and 2,4,6‐trichloro‐1,3,5‐triazine (TCT; cyanuric chloride) afforded an efficient cyanating agent which it can be used as a nontoxic, readily available, and non‐expensive reagent in the cyanation transformations. In this study, palladium‐catalyzed cyanation of aryl halides was successfully accomplished using this new “CN” source in high yields.