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Practical Solvent‐Free Microwave‐Assisted Hydroboration of Alkynes
Author(s) -
Altarejos Julia,
Sucunza David,
Vaquero Juan J.,
Carreras Javier
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000110
Subject(s) - hydroboration , chemistry , boron , solvent , adduct , organic chemistry , microwave irradiation , markovnikov's rule , microwave chemistry , microwave , combinatorial chemistry , catalysis , regioselectivity , physics , quantum mechanics
A simple and rapid protocol for the anti‐Markovnikov hydroboration of alkynes assisted by microwave irradiation has been developed. Pinacolborane smoothly reacts with terminal alkynes to obtain ( E )‐alkenyl boronates in good yields and short reactions times in the absence of solvent. Further transformations on the carbon‐boron bond of the adducts can be sequentially achieved without the need of purifying the alkenyl boronates.