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Heck Reactions of Acrolein or Enones and Aryl Bromides – Synthesis of 3‐Aryl Propenals or Propenones and Consecutive Application in Multicomponent Pyrazole Syntheses
Author(s) -
Stephan Marvin,
Panther Jesco,
Wilbert Fabio,
Ozog Pauline,
Müller Thomas J. J.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000066
Subject(s) - chemistry , aryl , acrolein , heck reaction , pyrazole , yield (engineering) , organic chemistry , medicinal chemistry , catalysis , alkyl , materials science , metallurgy
3‐(Hetero)aryl propenals or propenones are efficiently prepared by a Heck reaction of (hetero)aryl bromides and acrolein or vinyl ketones using Beller's CataCXium ® Ptb ligand under Jeffery's and Fu's conditions. The formation of these three‐carbon building blocks is embedded into consecutive three‐ and pseudo‐four‐component syntheses of 3‐(hetero)aryl and 3,5‐diarylpyrazoles with a broad substitution pattern in moderate to excellent yield.