Heck Reactions of Acrolein or Enones and Aryl Bromides – Synthesis of 3‐Aryl Propenals or Propenones and Consecutive Application in Multicomponent Pyrazole Syntheses | Zendy

Stephan Marvin | Zendy; Panther Jesco | Zendy; Wilbert Fabio | Zendy; Ozog Pauline | Zendy; Müller Thomas J. J. | Zendy

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Heck Reactions of Acrolein or Enones and Aryl Bromides – Synthesis of 3‐Aryl Propenals or Propenones and Consecutive Application in Multicomponent Pyrazole Syntheses

Author(s) -

Stephan Marvin,

Panther Jesco,

Wilbert Fabio,

Ozog Pauline,

Müller Thomas J. J.

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202000066

Subject(s) - chemistry , aryl , acrolein , heck reaction , pyrazole , yield (engineering) , organic chemistry , medicinal chemistry , catalysis , alkyl , materials science , metallurgy

3‐(Hetero)aryl propenals or propenones are efficiently prepared by a Heck reaction of (hetero)aryl bromides and acrolein or vinyl ketones using Beller's CataCXium ® Ptb ligand under Jeffery's and Fu's conditions. The formation of these three‐carbon building blocks is embedded into consecutive three‐ and pseudo‐four‐component syntheses of 3‐(hetero)aryl and 3,5‐diarylpyrazoles with a broad substitution pattern in moderate to excellent yield.

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