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Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition
Author(s) -
MéndezGálvez Carolina,
Böhme Matthias,
Leino Reko,
Savela Risto
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000046
Subject(s) - cobalt , chemistry , cycloaddition , catalysis , regioselectivity , diimine , steric effects , pyridine , combinatorial chemistry , ligand (biochemistry) , organic chemistry , receptor , biochemistry
Highly regioselective cobalt catalyzed [2+2+2] cycloaddition of diynes and monoynes to afford isobenzofuranones in good yields is described. The reaction proceeds in the presence of cheap and readily available cobalt catalyst with a sterically hindered pyridine‐2,6‐diimine ligand. Applicability of the method can also be extended to the synthesis of isoindolinones.