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Transition‐Metal Catalyzed Stereoselective γ‐Arylation and Friedel‐Crafts Alkylation: A Concise Synthesis of Indenes
Author(s) -
Ramesh Karu,
Satyanarayana Gedu
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000030
Subject(s) - chemistry , alkylation , friedel–crafts reaction , stereoselectivity , intramolecular force , catalysis , organic chemistry , divergent synthesis , solvent , transition metal , combinatorial chemistry
A highly stereoselective [Pd]‐catalyzed arylation of tert ‐alkenols, is presented and applied to the synthesis of indenes using intramolecular Friedel–Crafts alkylation sequence. The initial Heck reaction is performed by using water as the green solvent. A simple acid triggers intramolecular alkylation in short reaction times at room temperature. Notably, indenes have been accomplished using a single column chromatography technique.