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Direct Copper‐Catalyzed C‐H Monofluoroalkylation of Benzoxazoles with 1‐Fluoro‐1‐haloalkanes
Author(s) -
Li Wei,
Varenikov Andrii,
Gandelman Mark
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901929
Subject(s) - chemistry , copper , catalysis , stereochemistry , combinatorial chemistry , organic chemistry
The first example of direct C–H bond monofluoroalkylation with 1‐fluoro‐1‐haloalkanes with no adjacent functional groups and with β‐hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.