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Electrosynthesis of C3 Alkoxylated Quinoxalin‐2(1 H )‐ones through Dehydrogenative C–H/O–H Cross‐Coupling
Author(s) -
Jiang Xinpeng,
Yang Liechao,
Ye Zenghui,
Du Xiaofan,
Fang Liyun,
Zhu Yu,
Chen Keda,
Li Jianjun,
Yu Chuanming
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901928
Subject(s) - chemistry , electrosynthesis , electrochemistry , solvent , coupling (piping) , metal , functional group , combinatorial chemistry , organic chemistry , electrode , mechanical engineering , engineering , polymer
A highly efficient electrochemically dehydrogenative C–H/O–H cross‐coupling between quinoxalin‐2(1 H )‐ones and alcohols was developed under mild conditions. Using different types of alcohols as solvent, various 3‐alkoxylated quinoxalin‐2(1 H )‐ones were synthesized in a simple undivided cell at room temperature. This novel electrochemical cross‐dehydrogenative coupling approach features broad functional group tolerance, metal‐ and oxidant‐free conditions, and moderate to good yields.