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Ynones in Reflex‐Michael Addition, CuAAC, and Cycloaddition, as Well as their Use as Nucleophilic Enols, Electrophilic Ketones, and Allenic Precursors
Author(s) -
Wang ZhanYong,
Wang KaiKai,
Chen Rongxiang,
Liu Huan,
Chen Kaijun
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901921
Subject(s) - cycloaddition , chemistry , nucleophile , electrophile , azide , stereoselectivity , alkyne , nucleophilic addition , organic chemistry , combinatorial chemistry , catalysis
The great success of ynones in synthesis is rooted in their multiple functional groups. Herein, reactions triggered by the reflex‐Michael addition, ynones in copper(I)‐catalyzed alkyne–azide cycloaddition (CuAAC), and formal cycloaddition as well as the use of ynones as nucleophilic enols, electrophilic ketones, and allenic precursors were thoroughly discussed and summarized. Multi‐component reactions, rearrangements, cycloadditions, regio‐ and stereoselective synthesis, coupling, and cycloaddition are depicted in detail. This review focused on advances of ynones chemistry in the last decade (2009–2019). We hope it will promote future research in this area.