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Stereochemistry and Recent Applications of Axially Chiral Organic Molecules
Author(s) -
Mancinelli Michele,
Bencivenni Giorgio,
Pecorari Daniel,
Mazzanti Andrea
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901918
Subject(s) - chemistry , stereocenter , steric effects , atropisomer , organocatalysis , axial symmetry , molecule , enantioselective synthesis , organic molecules , stereochemistry , axial chirality , chiral column chromatography , computational chemistry , combinatorial chemistry , organic chemistry , high performance liquid chromatography , catalysis , structural engineering , engineering
This minireview covers the literature of the last decade related to the stereochemistry of axially chiral molecules. The first section reviews the use of dynamic NMR and dynamic HPLC for the ranking of the steric size of common organic moieties. The second and third sections describe the recent advances in the preparation of new atropisomeric scaffolds, and in the asymmetric synthesis of stereogenic axes by means of atroposelective organocatalysis.