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Cover Feature: Visible‐Light‐Induced Dearomatizations (Eur. J. Org. Chem. 10/2020)
Author(s) -
Okumura Mikiko,
Sarlah David
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901911
Subject(s) - chemistry , cover (algebra) , feature (linguistics) , benzene , combinatorial chemistry , aminocyclitol , aromaticity , visible spectrum , key (lock) , photochemistry , double bond , organic chemistry , molecule , optoelectronics , computer science , mechanical engineering , philosophy , linguistics , biochemistry , physics , aminoglycoside , computer security , engineering , antibiotics
The Cover Feature shows the key step, a visible‐light‐mediated dearomatization of benzene, that was used as a key step in the synthesis of pancratistatins. Specifically, arenophile‐mediated carboamination resulted in selective dearomative difunctionalization of a single double bond and enabled expedient preparation of highly functionalized aminocyclitol. This empowering transformation is one of many highlighted dearomatizations that utilize visible‐light photochemistry to break aromaticity. More information can be found in the Minireview by Okumura and D. Sarlah.