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Synthesis of N ‐Sulfonyl Pyrazoles Through Cyclization Reactions of Sulfonyl Hydrazines with Enaminones Promoted by p ‐TSA
Author(s) -
Zhang Qiaohe,
Hu Biao,
Zhao Yuxuan,
Zhao Siyun,
Wang Yanqin,
Zhang Biao,
Yan Shengjiao,
Yu Fuchao
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901886
Subject(s) - sulfonyl , chemistry , pyrazole , ring (chemistry) , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
A strategy for the rapid synthesis of 3‐substituted N ‐sulfonyl pyrazoles via p ‐TSA‐promoted cyclization reactions of sulfonyl hydrazines with N , N ‐dimethyl enaminones has been developed. This method achieves both the formation of pyrazole ring and the continued retention of sulfonyl group, providing a series of 3‐substituted N ‐sulfonyl pyrazoles in moderate to good yields with good functional group tolerance, easily available starting materials, and can be scaled‐up.