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Ruthenium‐Catalyzed meta ‐C Ar –H Bond Difluoroalkylation of 2‐Phenoxypyridines
Author(s) -
Jia Chunqi,
Wang Shichong,
Lv Xulu,
Li Gang,
Zhong Lei,
Zou Lei,
Cui Xiuling
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901883
Subject(s) - chemistry , ruthenium , catalysis , pyridine , medicinal chemistry , combinatorial chemistry , organic chemistry
A ruthenium‐catalyzed meta ‐selective C Ar –H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2,2‐difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2‐( meta ‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.