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Gold‐Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular 7 ‐ endo‐dig Cyclization
Author(s) -
Thummala Yadagiri,
Raju Chittala Emmaniel,
Purnachandar Dalovai,
Sreenivasulu Gottam,
Doddi Venkata Ramana,
Karunakar Galla V.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901852
Subject(s) - chemistry , regioselectivity , dig , intramolecular force , hydride , sodium hydride , medicinal chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , hydrogen , computer security , computer science
An efficient gold‐catalyzed intramolecular regioselective synthesis of pyrazolo[1,4]oxazepines were developed from alkynyl‐substituted pyrazoles via 7‐endo dig cyclization. In this reaction a new C–N bond was formed and substituted pyrazolo[1,4]oxazepines were obtained in moderate to very good yields. Whereas alkynyl‐substituted pyrazoles treated with sodium hydride produced the corresponding pyrazolo[1,4]oxazines regioselectively, via 6‐exo dig cyclization in one‐pot synthesis.