Gold‐Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular  7 ‐ endo‐dig  Cyclization | Zendy

Thummala Yadagiri | Zendy; Raju Chittala Emmaniel | Zendy; Purnachandar Dalovai | Zendy; Sreenivasulu Gottam | Zendy; Doddi Venkata Ramana | Zendy; Karunakar Galla V. | Zendy

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Gold‐Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular 7 ‐ endo‐dig Cyclization

Author(s) -

Thummala Yadagiri,

Raju Chittala Emmaniel,

Purnachandar Dalovai,

Sreenivasulu Gottam,

Doddi Venkata Ramana,

Karunakar Galla V.

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901852

Subject(s) - chemistry , regioselectivity , dig , intramolecular force , hydride , sodium hydride , medicinal chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , hydrogen , computer security , computer science

An efficient gold‐catalyzed intramolecular regioselective synthesis of pyrazolo[1,4]oxazepines were developed from alkynyl‐substituted pyrazoles via 7‐endo dig cyclization. In this reaction a new C–N bond was formed and substituted pyrazolo[1,4]oxazepines were obtained in moderate to very good yields. Whereas alkynyl‐substituted pyrazoles treated with sodium hydride produced the corresponding pyrazolo[1,4]oxazines regioselectively, via 6‐exo dig cyclization in one‐pot synthesis.

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