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Carbene‐Catalyzed Formal [3+3] Cycloaddition Reaction for Access to Substituted 2‐Phenylbenzothiazoles
Author(s) -
Ni Zhibin,
Mou Chengli,
Zhu Xun,
Qi Puying,
Yang Song,
Chi Yonggui Robin,
Jin Zhichao
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901773
Subject(s) - benzothiazole , cycloaddition , chemistry , carbene , catalysis , combinatorial chemistry , medicinal chemistry , reaction conditions , organic chemistry
A carbene‐catalyzed oxidative cycloaddition reaction is developed for efficient access to multi‐functionalized 2‐phenylbenzothiazoles. A broad scope of heavily substituted arenes bearing 2‐benzothiazole groups have been prepared in good to excellent yields. The remote C(sp 2 )–H bond in the substituted arene products can be activated by Pd catalysts in regio‐selective fashion with the direction of the 2‐benzothiazole groups.