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Metal‐Free Direct C–H Thiolation and Thiocyanation of Pyrazolones
Author(s) -
Kittikool Tanakorn,
Yotphan Sirilata
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901770
Subject(s) - pyrazolones , chemistry , pyrazolone , thiocyanate , thio , organic chemistry , green chemistry , combinatorial chemistry , reaction mechanism , catalysis
Metal‐free approach for direct C–H thiolation and thiocyanation of N ‐substituted pyrazolones with disulfides and thiocyanate salts, respectively, are developed. These reactions allow the C–S bond coupling to proceed effectively under mild conditions, providing useful and convenient methods for preparation of a series of 4‐thio‐substituted pyrazolone analogues, which have potential applications in organic, medicinal and material chemistry. Preliminary mechanistic investigation suggested that radical processes are likely to involve in these transformations.