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Transition‐Metal‐Free Synthesis of Electron Rich 1,3‐Dienes via Base Promoted Isomerization of Propargylic Ethers
Author(s) -
Liu Chunxiang,
Deng Guogang,
Li Xin,
Xu Yiren,
Yu Kaili,
Chen Wen,
Zhang Hongbin,
Yang Xiaodong
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901743
Subject(s) - isomerization , chemistry , transition metal , ether , organic chemistry , photochemistry , combinatorial chemistry , catalysis
Herein, a novel and scalable synthesis of electron rich 1,3‐dienes based on KO t Bu mediated isomerization of propargylic ether derivatives was developed. This new process features easy handling reaction conditions, transition‐metal‐free isomerization, high isolated yields, and most of all, it could be used for modification of natural products at late stage functionalizations.