Direct Amination of Isohexides via Borrowing Hydrogen Methodology: Regio‐ and Stereoselective Issues | Zendy

Bahé Florian | Zendy; Grand Lucie | Zendy; Cartier Elise | Zendy; Jacolot Maïwenn | Zendy; MoebsSanchez Sylvie | Zendy; Portinha Daniel | Zendy; Fleury Etienne | Zendy; Popowycz Florence | Zendy

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Direct Amination of Isohexides via Borrowing Hydrogen Methodology: Regio‐ and Stereoselective Issues

Author(s) -

Bahé Florian,

Grand Lucie,

Cartier Elise,

Jacolot Maïwenn,

MoebsSanchez Sylvie,

Portinha Daniel,

Fleury Etienne,

Popowycz Florence

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901661

Subject(s) - chemistry , stereoselectivity , amination , enantioselective synthesis , iridium , catalysis , alcohol , diamine , combinatorial chemistry , isosorbide , regioselectivity , reductive amination , hydrogen , monomer , enantiomeric excess , organic chemistry , polymer

The regio and diastereoselective direct mono or diamination of bio‐based isohexides (isosorbide and isomannide) has been developed through borrowing hydrogen (BH) methodology using a cooperative catalysis between an iridium complex and a Brønsted acid. The access to chiral amino‐alcohol (NH 2 ‐OH) and diamine (NH 2 ‐NH 2 ), interesting optically pure bio‐based monomers, was also proposed using BH strategy as a sustainable route for their obtention.

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