Regio‐ and Diastereoselective KMnO 4 /RCO 2 H Mediated Acyloxyarylation of Chalcones – An Indirect α‐Arylation of Chalcones | Zendy

Adib Mehdi | Zendy; RajaiDaryasarei Saideh | Zendy; Pashazadeh Rahim | Zendy; Mahdavi Mohammad | Zendy; Madadi Mozhdeh | Zendy; Jahani Mehdi | Zendy

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Regio‐ and Diastereoselective KMnO 4 /RCO 2 H Mediated Acyloxyarylation of Chalcones – An Indirect α‐Arylation of Chalcones

Author(s) -

Adib Mehdi,

RajaiDaryasarei Saideh,

Pashazadeh Rahim,

Mahdavi Mohammad,

Madadi Mozhdeh,

Jahani Mehdi

Publication year - 2020

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901647

Subject(s) - chemistry , chalcone , stereochemistry , sequence (biology) , organic chemistry , medicinal chemistry , biochemistry

A Mn VII ‐mediated regio‐ and diastereoselective acyloxyarylation of chalcones is unveiled. Heating a solution of a chalcone and an arylboronic acid in an aliphatic carboxylic acid at 80 °C for 1 h afforded the corresponding 1‐acyloxy‐3‐oxo‐1,2,3‐triarylpropanes in high yields. The β‐acyloxy‐α‐arylation/elimination sequence can be regarded as an indirect α‐arylation of chalcones.

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