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Cover Feature: Convenient Approach to 2‐Substituted (Thio)morpholin‐3‐ones from α‐Diazoacetates via X‐H Carbene Insertion – Lactamization Sequence (Eur. J. Org. Chem. 45/2019)
Author(s) -
Solovyov Igor,
Dar'in Dmitry,
Krasavin Mikhail
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901632
Subject(s) - chemistry , thio , carbene , diazo , insertion reaction , cover (algebra) , sequence (biology) , feature (linguistics) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , mechanical engineering , linguistics , philosophy , engineering
The Cover Feature shows the new convenient way of assembling medicinally important morpholinones and thiomorpholinones by reacting α‐diazo acetate esters with amino alcohols and amino thiols. The reaction involves RhII‐catalyzed O–H or S–H carbene insertion followed by lactamization. More information can be found in the Full Paper by M. Krasavin et al.