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Front Cover: Induction of Planar Chirality Using Asymmetric Click Chemistry by a Novel Desymmetrisation of 1,3‐Bisalkynyl Ferrocenes (Eur. J. Org. Chem. 43/2019)
Author(s) -
Wright Adam J.,
Hughes David L.,
Bulman Page Phillip C.,
Stephenson G. Richard
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901631
Subject(s) - chemistry , front cover , click chemistry , chirality (physics) , asymmetric induction , planar chirality , enantioselective synthesis , cover (algebra) , planar , stereochemistry , gaussian , computational chemistry , combinatorial chemistry , catalysis , organic chemistry , physics , computer graphics (images) , quantum mechanics , mechanical engineering , chiral symmetry breaking , computer science , nambu–jona lasinio model , engineering , quark
The Front Cover shows the first use of the new asymmetric CuAAC click reaction to induce planar stereogenicity. Stereodifferentiation in asymmetric induction (in the first CuAAC) and kinetic resolution (in the second CuAAC) are both influenced by ( R , R )‐Ph‐Pybox ligands on copper and so both contribute to the observed ees of the chiral monotriazole products. We acknowledge Daniel Starling for graphic design and QuteMol for images of space filling models of Ph‐Pybox which were generated from xyz data obtained by DFT calculations by the authors using Gaussian. More information can be found in the Full Paper by G. R. Stephenson et al.