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Synthesis of Cinnamides via Amidation Reaction of Cinnamic Acids with Tetraalkylthiuram Disulfides Under Simple Condition
Author(s) -
Lai Miao,
Wu Zhiyong,
Su Fangyao,
Yu Yujian,
Jing Yanqiu,
Kong Jinmin,
Wang Zhenteng,
Wang Shuai,
Zhao Mingqin
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901630
Subject(s) - chemistry , combinatorial chemistry , cinnamic acid , substrate (aquarium) , mixing (physics) , scope (computer science) , organic synthesis , organic chemistry , reaction conditions , catalysis , oceanography , physics , quantum mechanics , computer science , programming language , geology
A facile and efficient methodology for the synthesis of cinnamides has been achieved under metal‐ and additive‐free conditions. This method allows the efficient C–N cross‐coupling of diverse cinnamic acids with tetraalkylthiuram disulfides through a simply mixing operation in 1,2‐dichloroethane at 100 °C. The protocol provides a direct approach to cinnamides and is featured with readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.